Spirometry results after treatment for pulmonary tuberculosis: comparison between patients with and without previous lung disease: a multicenter study

Abstract:

Objective: To compare spirometry results after PTB treatment between patients with and without previous lung disease or smoking history, and to analyze risk factors related to functional severity.

Methods: A cross-sectional multicenter study was conducted at four referral centers in Brazil. Patients were divided into two groups: those with a history of lung disease or smoking (LDS+) and those without (LDS-). Spirometry was performed at least six months after the cure.

Results: Of the 378 patients included, 238 (62.7%) showed spirometric changes. Obstructive lung disease (OLD) predominated in the LDS+ group (33.3%), while restrictive lung disease (RLD) was more common in the LDS- group (24.7%). Notably, functional changes were found in 54% of LDS- patients who had normal or minimally altered chest X-rays ($p<0.01$).

Conclusion: Impaired pulmonary function is common after PTB treatment, regardless of prior lung health. Spirometry is recommended for patients with moderate/severe dyspnea or relevant radiological changes post-treatment.

Keywords: Tuberculosis, pulmonary; Respiratory function tests; Airway obstruction/complications.

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• Data de Publicação: 20/04/2020
• Autores: Eliane Viana Mancuzo1,2 , Eduardo Martins Netto3,4 , Nara Sulmonett2 , Vanessa de Souza Viana5 , Júlio Croda6 , Afranio Lineu Kritski7,8 , Fernanda Carvalho de Queiroz Mello7,9 , Simone de Souza Elias Nihues10 , Karen Rosas Sodre Azevedo11 , Silvana Spíndola de Miranda1,8,12