Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil

Abstract

Methods: We compared baseline clinical and demographic characteristics and determinants of anti-TB treatment outcomes between persons enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort ($N=1,060$) and the registry of TB cases reported to the Brazilian National TB Program (SINAN) ($N=455,873$) between June 2015 and June 2019. Multivariable regression models were performed using second-generation p-values.

Results: The cohorts were strikingly similar regarding sex, age, use of antiretroviral therapy, and positive initial smear sputum microscopy. However, diabetes, HIV infection, and smoking were more frequently documented in RePORT-Brazil. Illicit drug use was associated with unfavorable treatment outcomes in both cohorts.

Conclusions: There were important similarities in demographic characteristics and determinants of clinical outcomes between the RePORT-Brazil cohort and the Brazilian National registry. This representativeness supports the generalizability of results from the RePORT-Brazil study to the broader TB population in Brazil.

Keywords: Tuberculosis; Cohort study; Sample representativeness; Epidemiology; Treatment outcome.

Clique aqui

• Data de Publicação: 08/11/2020
• Autores: María B. Arriagaa,b,c , Gustavo Amorimd , Artur T.L. Queirozb,e , Moreno M.S. Rodriguesf , Mariana Araújo-Pereiraa,b,c , Betania M.F. Nogueirab,c,g,h,i , Alexandra Brito Souzaj,k , Michael S. Rochab,g , Aline Benjaminl , Adriana S.R. Moreiram, Jamile G. de Oliveiran , Marina C. Figueiredoo , Megan M. Turnero , Kleydson Alvesp , Betina Durovnim,q , José R. Lapa-e-Silvam, Afrânio L. Kritskim, Solange Cavalcantel,n , Valeria C. Rollal , Marcelo Cordeiro-Santosj,k , Timothy R. Sterlingo,1 , Bruno B. Andradea,b,c,h,o,r,s,1, *, for the RePORT Brazil consortium