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Hospital Santo Amaro
Referência em obstetrícia, neonatologia e cirurgias em geral
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IBIT
Matriz da FJS e destaque nacional no combate à tuberculose
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Soluções em Saúde para Empresas
Referência em soluções completas e personalizadas em Segurança do Trabalho, Saúde Ocupacional e Gestão Ambiental.
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Laboratório José Silveira
Qualidade e excelência em análises clínicas e anatomia patológica
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IBR
Modelo em reabilitação de casos de limitações psicomotoras
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Hospital Cristo Redentor
Atende a demanda de partos e de emergências em Itapetinga (BA)
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Centro de Reabilitação da Ribeira
Atendimento especializado a pacientes com deficiências
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Hospital Geral de Itaparica
Atendimento de urgência, obstétrico e cirúrgico
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Santa Casa de Jequié
Qualidade em assistência obstétrica e clínica em Jequié (BA)
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Saúde e Cidadania
Programa que leva saúde e assistência social a quem mais precisa
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NICSA - Memorial em Santo Amaro
Memorial em Santo Amaro
ABSTRACT: BACKGROUND: Hematological changes can drive damage of endothelial cells, which potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA). An association may exist between endothelial dysfunction and several clinical manifestations of SCA. The present study aims to evaluate the links between changes in endothelial function and clinical and laboratory parameters in children and adolescents with SCA.
METHODS: This study included 40 children and adolescents with stable SCA as well as 25 healthy children; aged 6-18 years. All study subjects were evaluated for endothelial function using Doppler ultrasonography. In addition, a number of laboratory assays were performed, including reticulocyte and leukocyte counts as well as measurement of circulating levels of total bilirubin, C-reactive protein (CRP), glucose, lipoproteins and peripheral oxyhemoglobin saturation. These parameters were also compared between SCA patients who were undertaking hydroxyurea (HU) and those who were not.
RESULTS: Flow-mediated vasodilation (FMD) values were found to be reduced in SCA patients compared with those detected in healthy controls. SCA individuals with lower FMD values exhibited higher number of hospital admissions due to vaso-occlusive events. Additional analyses revealed that patients who had decreased FMD values exhibited higher odds of acute chest syndrome (ACS) episodes. A preliminary analysis with limited number of individuals failed to demonstrate significant differences in FMD values between SCA individuals who were treated with HU and those who were not.
CONCLUSIONS: Children and adolescents with SCA exhibit impaired endothelial function. Reductions in FMD values are associated with ACS. These findings underline the potential use of FMD as screening strategy of SCA patients with severe prognosis at early stages.
- Data de Publicação: 01/09/2017
- Autores: Teixeira RS, Terse-Ramos R, Ferreira TA, Machado VR, Perdiz MI, Lyra IM, Nascimento VL, Boa-Sorte N, Andrade BB, Ladeia AM.