SARS-CoV-2 infection in pregnant women and newborns in two maternity hospitals in Salvador-Bahia, Brazil

Abstract:

We assessed epidemiological and clinical characteristics of patients with culture-confirmed pulmonary tuberculosis and their close contacts, enrolled in a multicenter prospective cohort in Brazil. Contacts were investigated at baseline and 6 months after enrollment. QuantiFERON positivity and conversion were compared between subgroups of contacts according to the glycemic status of persons with tuberculosis (PWTB). There were 592 PWTB and 1784 contacts, of whom 658 were QuantiFERON-positive at baseline and 106 were converters. Multivariable analyses demonstrated that tuberculosis-prediabetes cases, acid-fast bacilli-positive, pulmonary cavities, and living with someone who smoked were independently associated with QuantiFERON positivity at baseline. Diabetes mellitus (DM), persistent cough, acid-fast bacilli-positive, and pulmonary cavities in source cases were associated with QuantiFERON conversion.

Conclusions: Contacts of persons with pulmonary tuberculosis and dysglycemia were at increased risk of being QuantiFERON positive at baseline or month 6. Increased focus on such close contacts could improve tuberculosis control.

Keywords: diabetes; prediabetes; quantiFERON; interferon-γ releasing assay; Mycobacterium tuberculosis.

Clique aqui

• Data de Publicação: 25/05/2021
• Autores: Licia Maria Oliveira Moreiraa,Jesus Patiñob,* Patricia Ribeiro de Oliveiraac Maria Heloina Moura Costaa,c Ana Cecilia Santiago, Gúbio Soares Campos, Silvia Inês Sardi Carlos Menezes, Priscila Pinheiro Ribeiro Lyra, Eduardo Martins Nettob