Background:
Tuberculosis (TB) is a chronic inflammatory disease with highly diverse clinical presentations. While it causes tremendous morbidity worldwide, the determinants of disease heterogeneity and mortality—which is higher in India than in China—remain largely unknown. This study aimed to compare the systemic inflammatory perturbation at a molecular level between TB patients in these two high-burden countries.
Abstract:
Methods: We performed a cross-sectional study analyzing treatment-naïve pulmonary TB patients and healthy controls from India ($n=97$ TB; $n=20$ healthy) and China ($n=100$ TB; $n=11$ healthy). We employed the Molecular Degree of Perturbation (MDP) method to examine overall changes in 15 plasma protein and lipid biomarkers.
Results: M. tuberculosis infection caused significant molecular perturbation in both countries, but the overall degree was 3.7 times higher in Indian patients compared to Chinese patients ($p < 0.0001$). This higher perturbation in India was independent of clinical factors like age, sex, or disease severity. Network analyses identified IFN-$\alpha$, IFN-$\beta$, sIL-1RI, and TNF-$\alpha$ as key combined biomarkers driving the molecular perturbation across the entire study population.
Conclusions: Systemic inflammatory profiles in TB are significantly influenced by geographic region. These qualitative differences in inflammatory “stress” may reflect distinct host-pathogen interactions and could impact diagnosis and treatment strategies.
Keywords: tuberculosis; molecular degree of perturbation; biomarkers; systemic inflammation; epidemiology
Clique aqui
- Data de Publicação: 29/05/2019
- Autores: DeivideOliveira-de-Souza1,2,3, Caian L.Vinhaes1,2,3, MariaB.Arriaga1,2, NathellaPavanKumar4 , Juan M. Cubillos-Angulo1,2, Ruiru Shi5, WangWei5, XingYuan5, Guolong Zhang6, Ying Cai7, Clifton E. Barry III7, Laura E.Via7, Alan Sher8, Subash Babu4, Katrin D. Mayer-Barber 7, Helder I. Nakaya 9, Kiyoshi F. Fukutani 1,2,3 & Bruno B.Andrade 1,2,3,10,11
