Tuberculosis-associated anemia is linked to a distinct infammatory profle that persists after initiation of antitubercular therapy

Pulmonary tuberculosis (PTB) is associated with chronic infammation and anemia. How anemia impacts systemic infammation in PTB patients undergoing antitubercular therapy (ATT) is not fully understood. In the present study, data on several blood biochemical parameters were retrospectively analyzed from 118 PTB patients during the frst 60 days of ATT. Multidimensional statistical analyses were employed to perform detailed infammatory profling of patients stratifed by anemia status prior to treatment. Anemia was defned as hemoglobin levels <12.5g/dL for female and <13.5g/dL for male individuals. The fndings revealed that most of anemia cases were likely caused by chronic infammation. A distinct biosignature related to anemia was detected, defned by increased values of uric acid, C-reactive protein, and erythrocyte sedimentation rate. Importantly, anemic patients sustained increased levels of several biochemical markers at day 60 of therapy. Preliminary analysis failed to demonstrate association between persistent infammation during ATT with frequency of positive sputum cultures at day 60. Thus, TB patients with anemia exhibit a distinct infammatory profle, which is only partially reverted at day 60 of ATT.

• Data de Publicação: 04/02/2019
• Autores: LeonardoGil-Santana, LuísA. B. Cruz, María B.Arriaga, Pryscila F. C. Miranda, Kiyoshi F. Fukutani, Paulo S. Silveira-Mattos, ElisangelaC. Silva, MarinaG. Oliveira, Eliene D. D. Mesquita, Anneloek Rauwerdink, FrankCobelens, Martha M. Oliveira, Afranio Kritski & Bruno B.Andrade