Effect of dysglycemia on urinary lipid mediator profiles in persons with pulmonary

Background: Oxidized lipid mediators such as eicosanoids play a central role in the inflammatory response associated with tuberculosis (TB) pathogenesis. Diabetes mellitus (DM) leads to marked changes in lipid mediators in persons with TB. However, the associations between diabetes-related changes in lipid mediators and clearance of M. tuberculosis (Mtb) among persons on anti-TB treatment (ATT) are unknown. Quantification of urinary eicosanoid metabolites can provide insights into the circulating lipid mediators involved in Mtb immune responses.

Keywords: dysglycemia; Mycobacterium tuberculosis; urinary eicosanoids; lipid mediators; anti-tuberculosis treatment.

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• Data de Publicação: 08/07/2022
• Autores: María B. Arriaga, Farina Karim, Artur T.L. Queiroz, Mariana Araújo-Pereira, Beatriz Barreto-Duarte, Caio Sales, Mahomed-Yunus S. Moosa, Matilda Mazibuko, Ginger L. Milne, Fernanda Maruri, Carlos Henrique Serezani, John R. Koethe, Marina C. Figueiredo, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Valeria C. Rolla, Timothy R. Sterling, Alasdair Leslie, Bruno B. Andrade